The effects of Hyangbujapalmutang on the enhancement of learning and memory of AD model rats were studied with Morris water maze. Sample group was electrolytically lesioned on nucleus basalis of Meynert(nbM), and then daily treated with the medicine for two months. Control group with nbM lesion, and sham group with the sham operation were treated the vehicle for the same duration. The following results were observed.
1. As the learning trials of Morris water maze were proceeded, sham group showed the escape latency from 54.7±2.28 seconds in 1st trial to 13.3±3.27 seconds in 7th. The control group showed the escape latency from 58.0±1.78 seconds in 1st trial to 51.3±3.52 seconds in 7th. The sample group showed the escape latency from 57.0±2.21 seconds in 1st trial to 28.4±4.82 seconds in 7th. Therefore, these data shows that all three groups were improved in learning capacity as trials were proceeded, but the sample group showed more prominent improvement in learning compared with the control group(p〈0.05).
2. In memory retention test of Morris water maze that counts the staying time in the target area during 30 seconds of freely swimming period, sham group stayed for 4.81±1.15 seconds, the control group stayed for 1.27±0.78 seconds, and the sample group stayed for 4.17±1.47 seconds. The analysis of the memory retention data shows that the sample group marked more improvement in memory retention compared with the control group, but could not obtained statistically significant result(p〈0.05).
With the experimental results above, Hyangbujapalmultang can be supposed to have the improving effects on the learning of AD model rats induced by electrolytic lesion of nbM.
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